Thermo Fisher Scientific Bombesin Receptor 3 Polyclonal Antibody
Rabbit polyclonal antibody targeting Bombesin Receptor 3 (BRS3). Validated for IHC(P) at 10 µg/mL. High specificity for human, gorilla, and primate homologs. Supplied as liquid, unconjugated form in PBS with sodium azide. Ideal for GPCR-related research.
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- PA532676
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human BRS3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550139 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla (100%)
- Gibbon (95%)
- Monkey (90%)
- Bat, Elephant (85%)
- Horse, Rabbit, Guinea pig (80%)
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
Activating ligands induce conformational changes leading to signaling via G-proteins and downstream effectors. Studies show complex mechanisms of negative regulation (“turn-off” activity) influencing cellular physiology and driving pharmacological research for new drug candidates.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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