Thermo Fisher Scientific Bombesin Receptor 3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Bombesin Receptor 3 (BRS3). Validated for IHC (paraffin) at 10 µg/mL. High specificity with 100% identity to human and primate homologs. Supplied as liquid, 1 mg/mL, PBS with 0.1% sodium azide. For research ...
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 2nd extracellular domain of human BRS3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550142 |
Product Specific Information
- Percent identity with other species (BLAST analysis):
Human, Gorilla, Gibbon, Marmoset (100%); Monkey (95%); Bat, Panda, Rabbit (80%). - For IHC(P): Use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.
G-protein Coupled Receptors (GPCRs) constitute one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in both active and inactive forms. Activation involves ligand-induced conformational changes leading to G-protein signaling and downstream effects. Regulation of GPCR activity plays critical roles in cellular physiology and pharmacological research, with several GPCR-targeted drugs achieving major clinical and commercial success.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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