Thermo Fisher Scientific Bombesin Receptor 3 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) [IHC (P)]
  Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

• Percent identity with other species (BLAST analysis):
  Human, Gorilla, Gibbon, Marmoset (100%); Monkey (95%); Bat, Panda, Rabbit (80%).
• For IHC(P): Use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.

G-protein Coupled Receptors (GPCRs) constitute one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in both active and inactive forms. Activation involves ligand-induced conformational changes leading to G-protein signaling and downstream effects. Regulation of GPCR activity plays critical roles in cellular physiology and pharmacological research, with several GPCR-targeted drugs achieving major clinical and commercial success.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.