Thermo Fisher Scientific DcTRAILR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues C(155) S S S V S N P R N W L F L(168) of mouse DcTrailR1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DcTRAILR1,uniProtId:Q9ER63-1,ncbiNodeId:10090,antigenRange:155-168,antigenLength:176,antigenImageFileName:PA1-41657_DcTRAILR1_Q9ER63-1_Rabbit.svg,antigenImageFileNamePDP:PA1-41657_DcTRAILR1_Q9ER63-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein G

Storage buffer

PBS with 0.2% gelatin

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2207070

Product Specific Information

Suggested positive control: mouse spleen lysate or protein.

Target Information

Mouse DcTRAILR1 and DcTRAILR2 (decoy TRAIL receptors 1 and 2) proteins are receptors for TRAIL according to ligand-receptor binding assays (Schneider et al. 2001). However, overexpression does not cause NF-kB activation or apoptosis, as would be expected of a TRAIL receptor. These observations led researchers to refer to these receptors as decoys. It is thought that cells that express decoy TRAIL receptor decoys at high levels relative to actual TRAIL receptors may use decoys as protection against the cytotoxic action of TRAIL (reviewed in Bouralexis et al. 2005). Additional analysis of these two murine TRAIL decoy receptors should help faciliate the understanding of the complex biology underlying TRAIL ligand/receptor interactions. DcTRAILR1 is an amino acid protein of 176 amino acids (GenBank no: NP-077252.2). DcTRAILR2 is an amino acid protein of 198 amino acids (GenBank no: AAN87807.1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.