Thermo Fisher Scientific Phospho-FADD (Ser191) Polyclonal Antibody
FADD 단백질의 Ser191 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot과 IHC(P) 실험에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Suggested Positive Controls
- WB: Jurkat cells
- IHC: Human breast carcinoma
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of Serine191 (R-S-G(p)-A-M) derived from Mouse FADD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554376 |
Target Information
The FADD (Fas-Associated protein with Death Domain) protein is an adaptor molecule that mediates apoptotic signals from various cell surface receptors. Through its C-terminal death domain, it interacts with TNFRSF6/Fas receptor, TNFRSF25, and TNFSF10/TRAIL receptor, initiating death signaling. This interaction exposes the N-terminal effector domain, enabling recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice highlight its essential role in early T cell development.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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