Thermo Fisher Scientific Phospho-Claudin 6 (Tyr219) Polyclonal Antibody
Claudin 6 단백질의 Tyr219 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 Human 및 Mouse 시료에서 반응. 1 mg/mL 농도의 액상 형태로 제공되며, PBS(50% glycerol) 버퍼에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Suggested positive control: RAW264.7 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 219 (T-K-N-Y(p)-V) derived from Human Claudin 6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554379 |
Target Information
Tight junctions are specialized structures that mediate cell-to-cell adhesion in epithelial and endothelial layers, forming continuous seals around cells to regulate paracellular permeability. Claudin 6 is a component of these tight junction strands and belongs to the claudin family. It functions as an integral membrane protein and serves as one of the entry cofactors for hepatitis C virus. Gene methylation of Claudin 6 may play a role in esophageal tumorigenesis. The CLDN6 gene is located adjacent to CLDN9 on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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