Thermo Fisher Scientific TrkA Recombinant Rabbit Monoclonal Antibody (024)

Applications

Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:500

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Human TrkA/NTRK1.

Target Information

NTRK1 (TrkA) is a member of the neurotrophic factor family, essential for development and maintenance of the mammalian nervous system. TrkA acts as a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and MAPK pathway members.
Its presence induces cell differentiation and may determine sensory neuron subtypes.
Mutations in TrkA are associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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