Thermo Fisher Scientific beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (SU35-05)
Recombinant rabbit monoclonal antibody targeting beta-2 microglobulin for WB, ICC/IF, and IP applications. High specificity for human, mouse, and rat samples. Supplied as unconjugated liquid form, purified by Protein A, ideal for antigen processing and...
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SU35-05 |
| Immunogen | Synthetic peptide within C-terminal human beta-2 Microglobulin (UniProt ID: P61769-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2931483 |
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the MHC class I complex. It is expressed on various cell types such as lymphocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes.
It is also found free in plasma and shares sequence homology with immunoglobulin constant regions, exhibiting a beta-pleated sheet structure.
B2M participates in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells.
Encoded by the B2M gene on chromosome 15, mutations can lead to hypercatabolic hypoproteinemia.
B2M levels serve as markers for renal function in transplant recipients and as prognostic indicators in HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(해당 제품 관련 이미지: MA5-45029_beta-2_Microglobulin_P61769-1_Rabbit.svg, MA5-45029_beta-2_Microglobulin_P61769-1_Rabbit_PDP.jpeg)
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