Thermo Fisher Scientific Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (SN59-03)
Tyrosine Hydroxylase 단백질 검출용 재조합 토끼 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합함. HEK293 발현 시스템에서 생산되며 Protein A로 정제됨. 인간, 마우스, 랫트 반응성 보유.
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Thermo Fisher Scientific Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (SN59-03)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN59-03 |
| Immunogen | Synthetic peptide within C-terminal human Tyrosine Hydroxylase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931478 |
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters—dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with its cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate the enzyme.
Human TH has four splice variants (hTH1–hTH4) that differ in their N-terminal regulatory domains but share identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a critical role in adrenergic neuron physiology.
Alterations in TH activity are associated with neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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