Thermo Fisher Scientific Phospho-ATF2 (Thr69) Polyclonal Antibody
ATF2 단백질의 Thr69 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 IP에 사용 가능. SDS-PAGE 기준 95% 이상 순도, 55-75 kDa의 내인성 단백질 검출. 단기 4°C, 장기 -20°C 보관 권장.
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- PA536622
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- pk
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Thermo Fisher Scientific Phospho-ATF2 (Thr69) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human ATF2 around the phosphorylation site of Threonine 69 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553619 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 55–75 kDa.
- Purity >95% by SDS-PAGE.
Target Information
ATF-2 (also called CRE-BP1) is a transcription factor that binds to both AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with viral oncoproteins and cellular tumor suppressors and is a target of SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress such as genotoxic agents, inflammatory cytokines, and UV irradiation stimulates ATF-2 transcriptional activity.
Activation occurs via phosphorylation at Thr69 and Thr71, mediated by SAPK and p38 MAPK both in vitro and in transfected cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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