Thermo Fisher Scientific Human SKA3 Synthetic Peptide
인간 SKA3 단백질의 C-말단 13개 아미노산 서열 기반 합성 펩타이드. PA5-20819 항체의 블로킹 펩타이드로 사용 가능. 세포분열 시 방추체-키네토코어 상호작용 연구에 적합. 연구용으로만 사용.
- 카탈로그번호
- PEP0933
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human SKA3.
PEP-0933 can be used as a blocking peptide with polyclonal antibody PA5-20819.
Target Information
Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs.
A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset.
Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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