Thermo Fisher Scientific Human SKA1 Synthetic Peptide
Human SKA1 단백질의 C-말단 13개 아미노산에 해당하는 합성 펩타이드로, PA5-20817 항체의 블로킹 펩타이드로 사용 가능. 인간 유래, 액상 형태, 200 µg/mL 농도, PBS 버퍼에 0.1% BSA 포함. 연구용으로만 사용.
- 카탈로그번호
- PEP0931
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human SKA1.
PEP-0931 can be used as a blocking peptide with polyclonal antibody PA5-20817.
Target Information
Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs.
A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, is required for stable KT-MT interactions and timely anaphase onset.
Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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