Thermo Fisher Scientific TAB1 Monoclonal Antibody (F.211.6)
TAB1 단백질을 표적하는 Rabbit 모노클로날 항체로, WB 및 IP 실험에 적합. Human, Mouse, Rat 등 다양한 종에 반응. 액상 형태로 제공되며, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
- 판매단위
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.211.6 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Pro381 of human TAB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 25 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10977539 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminal region acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein functions as a mediator between TGF beta receptors and TAK1. TAB1 can also interact with and activate MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 responses to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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