Thermo Fisher Scientific Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody (NPM1/3285)
급성 골수성 백혈병(AML) 마커인 Nucleophosmin(NPM1)을 인식하는 단클론 항체. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. 인간 시료 반응성, Mouse IgG2c 아이소타입. 단백질 A/G 정제, 보존제 무첨가 PBS 용액 형태.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
| ELISA | 2–4 µg/mL |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NPM1/3285 |
| Immunogen | Recombinant human NPM1 protein fragment (aa 185–287) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly and transport, nucleocytoplasmic trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and p53 regulation. It shuttles between the nucleus, cytoplasm, and nucleolus, acting as a chaperone for core histones. NPM1 binds nucleic acids, prevents protein aggregation, protects enzymes from thermal denaturation, and assists in protein renaturation. It is associated with centrosomes and serves as a substrate of CDK2/cyclin E during centrosome duplication. NPM1 is implicated in several tumor-associated fusion proteins (e.g., NPM-ALK, NPM-RAR, NPM-MLF1) and may contribute to oncogenic transformation. Dysregulation of NPM1 is linked to acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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