Thermo Fisher Scientific Importin 4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 728-1081 of human IPO4 (NP_0789343) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Importin 4,uniProtId:Q8TEX9-1,ncbiNodeId:9606,antigenRange:728-1081,antigenLength:1081,antigenImageFileName:PA5-90575_Importin_4_Q8TEX9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90575_Importin_4_Q8TEX9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.94 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806126

Product Specific Information

Immunogen sequence: LHKACQSCPS EPNTAALQAA LARVVPSYMQ AVNRERERQV VMAVLEALTG VLRSCGTLTL KPPGRLAELC GVLKAVLQRK TACQDTDEEE EEEDDDQAEY DAMLLEHAGE AIPALAAAAG GDSFAPFFAG FLPLLVCKTK QGCTVAEKSF AVGTLAETIQ GLGAASAQFV SRLLPVLLST AQEADPEVRS NAIFGMGVLA EHGGHPAQEH FPKLLGLLFP LLARERHDRV RDNICGALAR LLMASPTRKP EPQVLAALLH ALPLKEDLEE WVTIGRLFSF LYQSSPDQVI DVAPELLRIC SLILADNKIP PDTKAALLLL LTFLAKQHTD SFQAALGSLP VDKAQELQAV LGLS; Positive Samples: HeLa, SH-SY5Y, A-549, HepG2, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Nucleus

Target Information

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.