Thermo Fisher Scientific GPR109 Polyclonal Antibody
GPR109A/HM74A/HCAR2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity Chromatography로 정제, PBS/glycerol buffer에 보존. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human GPR109A/HM74A/HCAR2 (NP_808219.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806128 |
Product Specific Information
- Immunogen sequence: KKMPIQNGGA NLCSSFSI
- Positive Samples: HepG2, Rat heart
Target Information
GPR109A (also known as HCA2, HM74a, and NIACR1) is a 42 kDa G-protein coupled receptor belonging to the hydroxyl-carboxylic acid receptor family, which includes GPR109B and GPR81.
It has two known ligands: niacin and butyrate (3-hydroxybutyrate).
GPR109A is expressed in adipocytes, neutrophils, Langerhans cells, keratinocytes, intestinal epithelial cells, and colonic macrophages.
Niacin (vitamin B3) improves cholesterol metabolism and reduces inflammation through GPR109A activation. GPR109A also plays a key role in suppressing inflammation and colon cancer.
In mice, its expression in intestinal epithelial cells and macrophages helps prevent colitis and colon cancer. In humans, GPR109A silencing by DNA methylation in colon carcinoma cells increases inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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