Thermo Fisher Scientific NFYA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 5–8 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

• Recommended positive controls: Jurkat
• Predicted reactivity: Cow (100%), Dog (100%), Guinea Pig (100%), Horse (100%), Mouse (100%), Rabbit (100%), Rat (100%), Yeast (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein – survival motor neuron protein. The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy types 1 and 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.