Thermo Fisher Scientific MMP19 Polyclonal Antibody
MMP19 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP에 적합합니다. HepG2 세포에서 양성 대조로 권장되며, 다양한 종에서 예측 반응성을 보입니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5–10 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunoprecipitation (IP) | – |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of human MMP-19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_560145 |
Product Specific Information
- Recommended positive control: HepG2
- Predicted reactivity: Cow (93%), Dog (93%), Guinea Pig (93%), Horse (79%), Mouse (86%), Rabbit (93%), Rat (93%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
MMP-19 (also known as RASI-1, MMP-18) is a 508 amino acid peptide originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients suggests that MMP-19 plays a role in RA-associated joint tissue destruction.
MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of RA patients, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggests a role in angiogenesis.
MMP-19 is expressed as a single 2.7 kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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