Thermo Fisher Scientific Kv2.2 Polyclonal Antibody
Rabbit polyclonal antibody targeting Kv2.2 (KCNB2) for detection in WB, IHC(P), and Flow Cytometry. Reacts with human and rat samples. Supplied in liquid form, 1 mg/mL, purified by antigen affinity chromatography. Suitable for neuroscience and ion chan...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within rat KV2.2 (aa 842–891) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890530 |
Target Information
Kcnb2 (Kv2.2) encodes a voltage-gated potassium channel that plays a key role in regulating neuronal membrane excitability. Variations in K+ channel expression and density influence action potential waveforms and repetitive firing in different neuronal types.
Delayed rectifier-type (IK) channels, including Kv1.5, Kv2.1, and Kv2.2, are found in neuronal somata, proximal dendrites, and various non-neuronal cells such as pancreatic islet, alveolar, and cardiac cells.
Kv2.1 and Kcnb2 form distinct K+ channel populations, primarily mediating IK in superior cervical ganglion cells. Functionally, Kcnb2 regulates voltage-dependent potassium ion permeability across excitable membranes.
Diseases associated with KCNB2 include Brugada Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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