Thermo Fisher Scientific ROBO1 Polyclonal Antibody

Thermo Fisher Scientific ROBO1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, A375
• Predicted reactivity: Mouse (93%), Rat (92%), Xenopus laevis (84%), Bovine (95%)
• IHC notes: Requires antigen retrieval using heat-mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Specialized cells at the midline, which separates the left and right halves of the CNS, have roles in directing growth cone behavior. In vertebrate spinal cord, insect ventral nerve cord, and C. elegans, midline cells produce guidance cues such as nectins and slit, acting as attractants and repellents. Robo functions as a receptor for the repellent Slit and defines a subfamily of Ig superfamily proteins conserved from fruit flies to mammals. Non-crossing axons express high levels of Robo, while crossing axons express low levels before reaching the midline and high levels after crossing. Robo1 and Robo2 are human homologs of the Drosophila Roundabout protein. Robo1 is homologous to the C. elegans gene sax3; Robo2 to the zebrafish gene astray.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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