Thermo Fisher Scientific Human DKK-1 Recombinant Protein, PeproTech
인간 DKK-1 재조합 단백질로 Wnt/β-catenin 신호 억제 연구에 적합. HEK293 세포에서 발현된 고순도(≥97%) 단백질. 기능적 활성 검증 완료. 실온 배송, -20°C 보관.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to 29 publications
Miscellaneous PubMed (Misc)
- Refer to 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse, Rat |
| Expression System | HEK293 cells |
| Amino Acid Sequence | TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH |
| Molecular Weight | 25.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 97% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | < 1 EU/µg |
| Activity | Inhibits mWnt3a-induced TCF/LEF-luciferase activity in HEK293 reporter cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Mature human DKK-1 expressed in HEK293 cells is a 35–40 kDa glycoprotein containing 235 amino acid residues. The calculated molecular weight of recombinant human DKK-1 expressed in HEK293 cells is 25.8 kDa.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
DKK-1 is a member of the DKK protein family, which includes DKK-2, DKK-3, and DKK-4. Initially identified as a Xenopus head-forming molecule, DKK-1 acts as an antagonist of Wnt signaling. It forms inhibitory complexes with LRP5 and LRP6, key co-receptors in the Wnt/β-catenin signaling pathway. By inhibiting Wnt/β-catenin signaling, DKK-1 enables anterior development in vertebrates. Mice deficient in DKK-1 expression lack head formation and die during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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