Thermo Fisher Scientific HEXA Polyclonal Antibody

Thermo Fisher Scientific HEXA Polyclonal Antibody

제품 사양

Product Specific Information

Immunogen sequence:
LESFYIQTLL DIVSSYGKGY VVWQEVFDNK VKIQPDTIIQ VWREDIPVNY MKELELVTKA GFRALLSAPW YLNRISYGPD WKDFYVVEPL AFE

Target Information

This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both subunits belong to family 20 of glycosyl hydrolases. Mutations in these genes cause accumulation of GM2 ganglioside in neurons, leading to neurodegenerative disorders termed GM2 gangliosidoses. Mutations in the alpha subunit gene result in Tay-Sachs disease (GM2-gangliosidosis type I).

주의 사항

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.