Thermo Fisher Scientific NR1I3 Monoclonal Antibody (OTI2H10), TrueMAB
NR1I3 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간 시료에 반응하며, 동결건조 형태로 제공됩니다. PBS 버퍼(8% 트레할로스 포함)에 용해 가능하며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–236 of human NR1I3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882) to ensure carrier-free conditions.
Target Information
This gene encodes a member of the nuclear receptor superfamily and is a key regulator of xenobiotic and endobiotic metabolism.
The protein binds to DNA as a monomer or as a heterodimer with the retinoid X receptor and regulates transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members.
Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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