Thermo Fisher Scientific CYP2D6 Polyclonal Antibody
CYP2D6 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 Protein A 정제, 안정적 액상 형태. 약물 대사 관련 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CYP2D6, amino acids 101–210 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze numerous reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP2D6 localizes to the endoplasmic reticulum and metabolizes approximately 20% of commonly prescribed drugs, including debrisoquine, sparteine, propafenone, and amitryptiline. The gene is highly polymorphic, with certain alleles leading to a poor metabolizer phenotype. It is located on chromosome 22q13.1 near two cytochrome P450 pseudogenes. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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