Thermo Fisher Scientific PALB2 Polyclonal Antibody
PALB2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 비결합형 액상 형태이며 4°C에서 보관합니다. BRCA1/BRCA2 복구 경로 연구 및 유방암 관련 단백질 분석에 활용됩니다.
- 카탈로그번호
- A301247AM
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PALB2 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 675–725 of PALB2 (UniProt ID: Q86YC2-1, NCBI Node ID: 9606) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Human
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer.
The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and, like BRCA1 and BRCA2, is a breast cancer susceptibility gene.
PALB2 functions by directly binding to BRCA1, organizing BRCA2 and the recombinase RAD51 at the site of DNA damage.
Analysis of the BRCA1–PALB2–BRCA2–RAD51 network may allow predictions of tumor responsiveness to therapeutic treatments.
At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.