Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Recombinant Rabbit Monoclonal Antibody (GATA3/7686R)

Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Recombinant Rabbit Monoclonal Antibody (GATA3/7686R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Human breast or urothelial carcinoma tissue
• Cellular Location: Nucleus

Target Information

The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 was shown to be an enhancer-binding protein containing a zinc finger domain and is abundantly expressed in the T-lymphocyte lineage, participating in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene consisting of six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by separate exons highly conserved with those of GATA1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.