Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Monoclonal Antibody (GATA3/2688)
GATA-3 단백질을 인식하는 단클론 항체로 유방암 및 요로상피암 마커 연구에 적합함. Western blot, Flow cytometry, ELISA 등 다양한 응용 가능. 인간 반응성, Mouse IgG1 kappa 형식, 고순도 Protein A/G 정제. 연구용으로만 사용.
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Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Monoclonal Antibody (GATA3/2688)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GATA3/2688 |
| Immunogen | Recombinant fragment of human GATA3 protein (around aa 357–436) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 is an enhancer-binding protein containing a zinc finger domain and is abundantly expressed in the T-lymphocyte lineage. It is thought to participate in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene, which comprises six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by separate exons highly conserved with those of GATA1, though no other structural homologies between the two genes were found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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