Thermo Fisher Scientific FZD8 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse Frizzled-9 is observed.
• Less than 1% cross-reactivity with rmFrizzled-1, -2, -3, -4, -6, and -7 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS prior to use.

Target Information

Members of the Frizzled family encode seven-transmembrane domain proteins that function as receptors for the Wingless-type MMTV integration site family of signaling proteins.
Most Frizzled receptors are associated with the β-catenin canonical signaling pathway.

Frizzled 8 (FZD8) is highly expressed in several human cancer cell lines, suggesting a potential role in tumorigenesis. Expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle.
ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries.
The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.