Thermo Fisher Scientific FZD8 Polyclonal Antibody
마우스 FZD8 단백질을 인식하는 폴리클로날 항체로, WB와 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. PBS 및 5% 트레할로스 버퍼에 재구성하여 사용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (IHC) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-8 (Ala25–Pro173) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607397 |
Product Specific Information
- In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse Frizzled-9 is observed.
- Less than 1% cross-reactivity with rmFrizzled-1, -2, -3, -4, -6, and -7 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS prior to use.
Target Information
Members of the Frizzled family encode seven-transmembrane domain proteins that function as receptors for the Wingless-type MMTV integration site family of signaling proteins.
Most Frizzled receptors are associated with the β-catenin canonical signaling pathway.
Frizzled 8 (FZD8) is highly expressed in several human cancer cell lines, suggesting a potential role in tumorigenesis. Expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle.
ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries.
The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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