Thermo Fisher Scientific CACNG1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CACNG1. Suitable for WB and IHC applications. Lyophilized form without preservative. Cross-reactive with mouse and rat. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human CACNG1 (CACNLG) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity: CACNG1.
Target Information
Voltage-dependent calcium channels are essential for neurotransmitter release. L-type (long-lasting current) voltage-dependent calcium channels consist of four subunits: alpha1, beta, gamma, and alpha2 delta. The beta subunit is encoded by four genes (beta1–beta4), contributing to calcium current diversity and membrane trafficking of the alpha1 subunit.
L-type Ca²⁺ channel gamma1 (also known as CACNLG or CACNG1) is a 222 amino acid multi-pass membrane protein of the PMP-22/EMP/MP20 family. It is expressed in skeletal muscle and acts as a subunit of the dihydropyridine (DHP)-sensitive calcium channel, potentially involved in excitation–contraction coupling. CACNG1 is also considered a marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant skeletal muscle disorder that can trigger hypermetabolic crises under certain anesthetics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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