Thermo Fisher Scientific Neuropilin-1 Recombinant Rabbit Monoclonal Antibody (ARC0488)
Neuropilin-1 단백질을 인식하는 재조합 토끼 단클론 항체로, WB 및 ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현된 IgG 형식. 높은 특이성과 재현성을 제공하며 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0488 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 824–923 of human Neuropilin-1 (NRP1) (O14786) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849156 |
Product Specific Information
Immunogen sequence:
IDETGSTPGY EGEGEGDKNI SRKPGNVLKT LDPILITIIA MSALGVLLGA VCGVVLYCAC WHNGMSERNL SALENYNFEL VDGVKLKKDK LNTQSTYSEA
Target Information
Neuropilin 1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin 1 forms a heterodimer with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors. Predominantly expressed in the nervous system, this receptor plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, and organogenesis. It also acts as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis. Neuropilin 1 may be involved in advanced prostate carcinoma and breast cancer progression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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