Thermo Fisher Scientific Bcl-X (Apoptosis Marker) Recombinant Rabbit Monoclonal Antibody (BCL2L1/4509R)
Bcl-X 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. 세포자멸사(apoptosis) 연구용으로 적합하며, IHC(PFA 고정)에서 1–2 µg/mL 농도로 사용됩니다. 단백질 A/G로 정제된 액상 형태로, -20°C에서 보관합니다.
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Applications
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BCL2L1/4509R |
| Immunogen | Recombinant fragment (around aa1–100) of human BCL2L1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
These proteins are located at the outer mitochondrial membrane and regulate the opening of the mitochondrial membrane channel (VDAC). VDAC controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — key factors in cell apoptosis.
Alternative splicing produces multiple transcript variants encoding two isoforms:
- Longer isoform: acts as an apoptotic inhibitor
- Shorter isoform: acts as an apoptotic activator
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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