Thermo Fisher Scientific MAP3K8 Monoclonal Antibody (OTI3D9), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

MAP3K8 (COT) is a serine/threonine kinase that activates both MAP and JNK kinase pathways and plays a role in the cell cycle.
MAPK signaling cascades include MAPK/ERK, MAPK kinase (MEK), and MAPK kinase kinase (MEKK).
MEKK8 can activate NF-kappa-B1 by promoting proteasome-mediated proteolysis of NF-kappa-B1/p105.
This cytoplasmic protein is expressed in various normal tissues and tumor-derived cell lines.
The 58 kDa form is activated during S and G2/M phases, while phosphorylation occurs mainly on Ser residues in the longer form and on both Ser and Thr residues in the shorter form.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.