Thermo Fisher Scientific KSR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 366-490. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KSR1,uniProtId:Q8IVT5-1,ncbiNodeId:9606,antigenRange:366-490,antigenLength:923,antigenImageFileName:PA5-144704_KSR1_Q8IVT5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144704_KSR1_Q8IVT5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092000

Product Specific Information

Immunogen sequence: SMIFGVKCKH CRLKCHNKCT KEAPACRISF LPLTRLRRTE SVPSDINNPV DRAAEPHFGT LPKALTKKEH PPAMNHLDSS SNPSSTTSST PSSPAPFPTS SNPSSATTPP NPSPGQRDSR FNFPA

Antigen sequence identity: Mouse 96%; Rat 95%

Target Information

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.