Thermo Fisher Scientific Factor XII Polyclonal Antibody
Factor XII 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, 안정한 PBS/glycerol buffer 보존. 연구용으로 혈액 응고 관련 단백질 분석에 활용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 336–615 of human F12 (NP_0004962) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901334 |
Product Specific Information
- Positive Samples: HepG2, MCF7, Mouse liver
- Immunogen sequence:
QTPGALPAKR EQPPSLTRNG PLSCGQRLRK SLSSMTRVVG GLVALRGAHP YIAALYWGHS FCAGSLIAPC WVLTAAHCLQ DRPAPEDLTV VLGQERRNHS CEPCQTLAVR SYRLHEAFSP VSYQHDLALL RLQEDADGSC ALLSPYVQPV CLPSGAARPS ETTLCQVAGW GHQFEGAEEY ASFLQEAQVP FLSLERCSAP DVHGSSILPG MLCAGFLEGG TDACQGDSGG PLVCEDQAAE RRLTLQGIIS WGSGCGDRNK PGVYTDVAYY LAWIREHTVS
Target Information
Factor XII is a single-chain zymogen converted to a two-chain serine protease composed of a heavy chain (alpha-factor XIIa) and a light chain.
- Heavy chain: contains fibronectin-type domains, EGF-like domains, kringle domain, and proline-rich domain
- Light chain: contains catalytic domain
Upon activation, further cleavage produces beta-factor XIIa. Factor XII plays a key role in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.
Defects in this gene prolong whole-blood clotting time but do not cause clinical symptoms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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