Thermo Fisher Scientific PSD-95 Recombinant Rabbit Monoclonal Antibody (1H4)
PSD-95 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 적합. 인간, 생쥐, 랫트 시료에 반응하며 HEK293 세포에서 발현됨. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H4 |
| Immunogen | A synthesized peptide derived from human PSD95 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3094122 |
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, an SH3 domain, and a GuK domain. It plays a key role in clustering NMDA receptors and Shaker-type potassium channels at the synaptic membrane in central nervous system neurons.
Two principal modes of interaction exist between PSD-95 and other proteins:
- NMDA receptors and Shaker-type potassium channels share a C-terminal T/SXV motif that binds to PSD-95 PDZ domains.
- Neuronal nitric oxide synthase (nNOS), lacking the T/SXV motif but containing its own PDZ domain, interacts with PSD-95 through PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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