Thermo Fisher Scientific MYBBP1A Recombinant Rabbit Monoclonal Antibody (3A1)
인간 MYBBP1A 단백질을 인식하는 재조합 토끼 단클론 항체. IHC, ICC/IF, ELISA 등 다양한 응용 가능. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현된 액상 형태. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:20–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3A1 |
| Immunogen | A synthesized peptide derived from human MYBBP1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092627 |
Target Information
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth, and transactivating gene expression.
c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, with cellular levels decreasing as cells reach terminal differentiation.
Myb-binding protein 1A (MYBBP1A) is a nuclear protein localized predominantly in nucleoli. Initially identified as a c-Myb-interacting protein, MYBBP1A is ubiquitously expressed and associates with various transcription factors. It interacts with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression.
MYBBP1A also acts as a negative regulator of PPAR gamma coactivator 1 alpha (PGC-1α) via p38 MAPK and functions as a nucleocytoplasmic shuttling protein utilizing CRM1-dependent and independent nuclear export pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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