Thermo Fisher Scientific MYBBP1A Recombinant Rabbit Monoclonal Antibody (3A1)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:20–1:200

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth, and transactivating gene expression.
c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, with cellular levels decreasing as cells reach terminal differentiation.

Myb-binding protein 1A (MYBBP1A) is a nuclear protein localized predominantly in nucleoli. Initially identified as a c-Myb-interacting protein, MYBBP1A is ubiquitously expressed and associates with various transcription factors. It interacts with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression.
MYBBP1A also acts as a negative regulator of PPAR gamma coactivator 1 alpha (PGC-1α) via p38 MAPK and functions as a nucleocytoplasmic shuttling protein utilizing CRM1-dependent and independent nuclear export pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.