Thermo Fisher Scientific RAB5 Recombinant Rabbit Monoclonal Antibody (ARC0297)
RAB5 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, HEK293 세포에서 발현된 IgG 형식입니다. 고순도 친화 크로마토그래피 정제 및 안정한 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0297 |
| Immunogen | A synthetic peptide corresponding to amino acids 116–215 of human RAB5AA (P20339) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849066 |
Product Specific Information
Immunogen sequence:
KELQRQASPN IVIALSGNKA DLANKRAVDF QEAQSYADDN SLLFMETSAK TSMNVNEIFM AIAKKLPKNE PQNPGANSAR GRGVDLTEPT QPTRNQCCSN
Target Information
RAB5 belongs to the small GTPase Rab family, which regulates intracellular membrane trafficking from vesicle formation to membrane fusion. Rabs alternate between an inactive GDP-bound state and an active GTP-bound state that recruits downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
RAB5A plays an essential role in plasma membrane and early endosome fusion, filopodia extension, and exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also regulates the maturation of apoptotic cell-containing phagosomes, likely downstream of DYN2 and PIK3C3.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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