Thermo Fisher Scientific IDH3G Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• This antibody is expected to recognize both reported isoforms (NP_004126.1; NP_777358.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses: one utilizes NAD(+) as the electron acceptor and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases (mitochondrial matrix localized) and two NADP(+)-dependent isocitrate dehydrogenases (one mitochondrial, one cytosolic).
NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer composed of two alpha subunits, one beta subunit, and one gamma subunit.
The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase and is a candidate gene for periventricular heterotopia.
Several alternatively spliced transcript variants have been described, though only some full-length forms have been determined.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.