Thermo Fisher Scientific SOD2 (MnSOD) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.01–0.03 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize isoform A (NP_000627.2) only.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS).
SOD catalyzes the dismutation of superoxide radical anion (O₂⁻) to hydrogen peroxide, which is further converted to water and oxygen by glutathione peroxidase and catalase.

There are several classes of SOD:

• SOD1 (Cu,Zn-SOD): Intracellular, homodimeric 32 kDa enzyme containing Cu and Zn ions per subunit.
• SOD2 (Mn-SOD): Mitochondrial, 80 kDa tetrameric enzyme located in the mitochondrial matrix near the respiratory chain.
• SOD3 (EC-SOD): Extracellular, heparin-binding multimer expressed in lungs, vessel walls, and airways.
• SOD4 (CCS): Copper chaperone that delivers Cu to SOD1 and activates it through cofactor insertion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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