Thermo Fisher Scientific GABA A Receptor alpha 1 Polyclonal Antibody
Thermo Fisher Scientific의 GABA A Receptor alpha 1 폴리클로날 항체는 인간, 마우스, 랫트에서 반응하며 WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. KLH 결합 합성 펩타이드 면역원으로 제작되었으며, 고순도 Protein A 정제 항체로 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GABRA1, amino acids 301–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, inducing hyperpolarization through Cl⁻ channel opening associated with the GABAA receptor (GABAA-R) subtype.
GABAA-Rs serve as therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in epilepsy, anxiety, depression, and substance abuse.
These receptors are multimeric subunit complexes composed of various alpha, beta, and gamma subunits, including splicing variants. Expression of alpha and beta subunits alone yields GABA-sensitive receptors, while coexpression with gamma subunits enables benzodiazepine modulation.
Phosphorylation of beta subunits further modulates GABAA-R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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