Thermo Fisher Scientific SCF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Stem Cell Factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting potential therapeutic relevance in inflammatory diseases like asthma. At least two isoforms of SCF are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.