Thermo Fisher Scientific FAIM3 Polyclonal Antibody
Thermo Fisher Scientific의 FAIM3 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot 및 ELISA에 적합합니다. 재조합 FAIM3 단백질(aa 18–251)을 면역원으로 사용한 고품질 항체로, 액상 형태이며 -20°C에서 보관합니다. 연구용 전용 시약입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 18–251 of human FAIM3 (NP_005440.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855117 |
Product Specific Information
Immunogen sequence:
RILPEVKVEG ELGGSVTIKC PLPEMHVRIY LCREMAGSGT CGTVVSTTNF IKAEYKGRVT LKQYPRKNLF LVEVTQLTES DSGVYACGAG MNTDRGKTQK VTLNVHSEYE PSWEEQPMPE TPKWFHLPYL FQMPAYASSS KFVTRVTTPA QRGKVPPVHH SSPTTQITHR PRVSRASSVA GDKPRTFLPS TTASKISALE GLLKPQTPSY NHHTRLHRQR ALDYGSQSGR EGQG
Target Information
Apoptosis is a key process for maintaining normal tissue homeostasis. Activation of the Fas receptor by its ligand triggers formation of a Fas-associated death domain (FADD)-containing signaling complex and activation of caspase-8, which subsequently activates downstream caspases such as caspase-3 and -7.
Overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, renders Jurkat and transgenic mouse cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Toso associates with FADD, suggesting it disrupts formation of the death-inducing signaling complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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