Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (UMAB37), UltraMAB
CD20 (MS4A1) 단백질을 인식하는 UMAB37 클론의 Mouse IgG1 단일클론 항체. 인간 시료에 반응하며 IHC(P)에서 1:150 희석으로 사용 가능. Lyophilized 형태로 제공되며 PBS, trehalose buffer에 보관. 연구용으로 B세포 표지 및 면역조직화학 분석에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB37 |
| Immunogen | Full length human recombinant protein of human MS4A1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells.
It regulates calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 remains at the cell surface after receptor ligation and serves as an effective target for antibody-mediated B-cell depletion in malignancies.
Dysfunction of CD20 is associated with Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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