Thermo Fisher Scientific BIN1 Recombinant Rabbit Monoclonal Antibody (23GB3010)
BIN1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, Western blot과 유세포분석에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293F 세포에서 발현된 액상형 항체로 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Thermo Fisher Scientific BIN1 Recombinant Rabbit Monoclonal Antibody (23GB3010)
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:5,000
- Flow Cytometry (Flow): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3010 |
| Immunogen | A synthesized peptide derived from human BIN1 (400–593AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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