Thermo Fisher Scientific Androgen Receptor Recombinant Rabbit Monoclonal Antibody (23GB2975)

Applications and Tested Dilution

Product Specifications

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor (~90 kDa) has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, it dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.

The AR signaling pathway is essential for the development and function of male reproductive organs (prostate, epididymis) and also plays roles in nonreproductive tissues (muscle, hair follicles, brain). AR is a phosphoprotein that regulates MAP kinase signaling, and inhibition of the MEK1/2 pathway affects AR phosphorylation. Dysregulation of AR signaling is linked to diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene are associated with complete androgen insensitivity (CAIS).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.