Thermo Fisher Scientific Fra1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls: HeLa, C6
• Localization: Nucleus

Immunogen sequence:
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI

Target Information

The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1, and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by various agents and function as transcriptional regulators for several genes.
In contrast to c-Jun proteins, which form homo- and heterodimers that bind specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Selected ATF/CREB family members can also form leucine zipper dimers with Fos and Jun, exhibiting differential specificity and affinity for AP-1 and CRE sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.