Thermo Fisher Scientific Human PHAP Synthetic Peptide
인간 PHAP 단백질의 카복시 말단 서열에 해당하는 합성 펩타이드로, PA5-20026 항체의 블로킹 펩타이드로 사용 가능. 세포사멸 관련 연구에 적합하며, 고순도 정제 상태로 제공. PBS(pH 7.2) 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to amino acids near the carboxy terminus of human PHAP.
PEP-0145 can be used as a blocking peptide with polyclonal antibody PA5-20026.
Target Information
Apoptosis is related to many diseases and developmental processes. Caspase-9 plays a central role in cell death induced by various apoptosis activators. Cytochrome c, after being released from mitochondria, binds to Apaf-1 to form an apoptosome, which then binds to and activates procaspase-9. Activated caspase-9 cleaves and activates effector caspases (caspase-3, -6, and -7), responsible for proteolytic cleavage of key proteins in apoptosis.
The tumor suppressor putative HLA-DR-associated proteins (PHAPs) have been identified as important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation and stimulates the mitochondrial apoptotic pathway. It also opposes Ras- and Myc-mediated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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