Thermo Fisher Scientific Human TIRAP Synthetic Peptide

Thermo Fisher Scientific Human TIRAP Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 20 amino acids near the center of human TIRAP.
PEP-0146 can be used as a blocking peptide with polyclonal antibody PA5-20027.

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.
In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling.
Furthermore, these mice are resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.