Thermo Fisher Scientific Human PHAP Synthetic Peptide
Human PHAP 합성 펩타이드로, 인간 단백질의 아미노 말단 서열에 해당합니다. 폴리클로날 항체 PA5-20024의 차단 펩타이드로 사용 가능하며, 세포 사멸 연구에 적합합니다. 고순도 정제된 액상 형태로 제공되며, PBS/BSA 완충액에 보관됩니다.
- 카탈로그번호
- PEP0143
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to amino acids near the amino terminus of human PHAP.
PEP-0143 can be used as a blocking peptide with polyclonal antibody PA5-20024.
Target Information
Apoptosis is related to many diseases and developmental processes. Caspase-9 plays a central role in cell death induced by various apoptosis activators.
Cytochrome c, after release from mitochondria, binds to Apaf-1 to form an apoptosome, which subsequently activates procaspase-9.
Activated caspase-9 then cleaves and activates effector caspases (caspase-3, -6, and -7), responsible for proteolytic cleavage of key apoptosis-related proteins.
PHAP (Putative HLA-DR-associated proteins) are identified as important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation and stimulates the mitochondrial apoptotic pathway, while opposing Ras- and Myc-mediated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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