Thermo Fisher Scientific NKCC1 Polyclonal Antibody
Thermo Fisher Scientific의 NKCC1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot, IHC, ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, 막 단백질 NKCC1 검출에 유용하며 세포 내 이온 균형 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 120–280 of human SLC12A2 (NP_0010371) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.26 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804742 |
Product Specific Information
- Positive Samples: Mouse pancreas, Rat brain
- Cellular Location: Membrane, Multi-pass membrane protein
Immunogen sequence:
GEASGESEPA KGSEEAKGRF RVNFVDPAAS SSAEDSLSDA AGVGVDGPNV SFQNGGDTVL SEGSSLHSGG GGGSGHHQHY YYDTHTNTYY LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLAELHDE LEKEPFEDGF ANGEESTPTR DAVVTYTAES K
Target Information
NKCC1 mediates sodium and chloride transport and reabsorption. It is a membrane protein essential for maintaining ionic balance and cell volume. NKCC1 functions as an electrically silent transporter system and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been identified.
Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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