Thermo Fisher Scientific NKCC1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human SLC12A2 (NP_0010371) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NKCC1,uniProtId:P55011-1,ncbiNodeId:9606,antigenRange:120-280,antigenLength:1212,antigenImageFileName:PA5-88206_NKCC1_P55011-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88206_NKCC1_P55011-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.26 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804742

Product Specific Information

Positive Samples: Mouse pancreas, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein

Immunogen sequence: GEASGESEPA KGSEEAKGRF RVNFVDPAAS SSAEDSLSDA AGVGVDGPNV SFQNGGDTVL SEGSSLHSGG GGGSGHHQHY YYDTHTNTYY LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLAELHDE LEKEPFEDGF ANGEESTPTR DAVVTYTAES K

Target Information

NKCC1 mediates sodium and chloride transport and reabsorption. NKCC1 is a membrane protein and is important in maintaining proper ionic balance and cell volume. NKCC1 is an electrically silent transporter system that mediates sodium and chloride reabsorption. Further, NKCC1 plays a vital role in the regulation of ionic balance and cell volume and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for NKCC1. Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.