Thermo Fisher Scientific Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12), FITC
FITC로 표지된 재조합 토끼 단일클론 항체로, 인간 Aurora A/B/C 단백질의 인산화 부위를 인식합니다. Flow Cytometry에 적합하며, 고순도 Protein A/G 정제 및 안정적 PBS-BSA 완충액에 보존됩니다. 세포 분열 및 유사분열 연구에 유용합니다.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AuroraABC-CC12 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288) / Aurora B (Thr232) / Aurora C (Thr198) |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897334 |
Additional Formats
- Unconjugated (MA5-37152)
- APC (MA5-37155)
- PE (MA5-37153)
- Custom conjugation available upon request
Target Information
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a key regulator of mitosis.
The CPC ensures correct chromosome alignment and segregation, required for chromatin-induced microtubule stabilization and spindle assembly.
Aurora kinases are essential for cytokinesis, spindle assembly, and checkpoint control.
AURKB phosphorylates multiple substrates including BIRC5, CDCA8, INCENP, and histone H3, regulating mitotic progression and chromatin dynamics.
Also involved in kinetochore localization of BUB1 and SGOL1 and negative regulation of p53 transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures.
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